Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response01:15

Chronopharmacokinetics: Circadian Rhythms and Influence on Drug Response

57
Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
The time of drug administration is an important factor to consider, as it can influence the toxic dose of a drug. For example, a study conducted by Prins et al. in 1997 examined the effects of the timing of...
57
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

55
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
55
Sedatives and Hypnotics Drugs: Miscellaneous Agents01:17

Sedatives and Hypnotics Drugs: Miscellaneous Agents

168
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
168
Management of Insomnia01:19

Management of Insomnia

244
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
244
Antidepressant Drugs: MAOIs and Other Agents01:23

Antidepressant Drugs: MAOIs and Other Agents

220
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
220
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

2.0K
When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.0K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Aripiprazole Lauroxil: Development and Evidence-Based Review of a Long-Acting Injectable Atypical Antipsychotic for the Treatment of Schizophrenia.

Neuropsychiatric disease and treatment·2025
Same author

Esketamine nasal spray versus quetiapine XR in adults with treatment-resistant depression: a secondary analysis of the ESCAPE-TRD randomized clinical trial.

CNS spectrums·2025
Same author

Expert consensus statement for telepsychiatry and attention-deficit hyperactivity disorder.

CNS spectrums·2024
Same author

Understanding the mechanism of action and clinical effects of neuroactive steroids and GABAergic compounds in major depressive disorder.

Translational psychiatry·2023
Same author

Long-term safety and efficacy, including anhedonia, of vortioxetine for major depressive disorder: findings from two open-label studies.

Current medical research and opinion·2023
Same author

Assessing the educational needs of physicians in the management of patients with Tourette syndrome: results of a United States survey on practicing clinicians and caregivers.

CNS spectrums·2022

相关实验视频

Updated: Jun 23, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

15.7K

所有的ADHD药物都是平等的吗? 探索使晚上用药成为可能的差异.

Gregory W Mattingly1,2,3, Julie A Carbray4, Perry Roy5

  • 1Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA.

Postgraduate medicine
|June 21, 2024
PubMed
概括

新的延迟释放和延长释放甲基化物 (DR/ER-MPH) 为注意力缺陷/多动症障碍 (ADHD) 提供了一种新的晚上剂量选择. 本综述检查了其特征和对ADHD患者的临床实用性.

关键词:
氨基胺是一种安非他命.延缓释放和延长释放的甲基化物.剂量 剂量 剂量 剂量 剂量持续时间 持续时间延长期释放的延长期释放长时间起作用的药物.甲基化甲基化药物动力学 药物动力学药物治疗药物治疗

更多相关视频

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

5.7K
Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.4K

相关实验视频

Last Updated: Jun 23, 2025

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
10:02

Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD

Published on: March 12, 2020

15.7K
The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
05:48

The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients

Published on: June 12, 2020

5.7K
Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.4K

科学领域:

  • 药理学和精神病学 药理学和精神病学
  • 神经科学和行为科学 神经科学和行为科学

背景情况:

  • 注意缺陷/多动障碍 (ADHD) 治疗涉及30多种兴奋剂药物,主要是安非他胺或甲基胺变体.
  • 多样化的配方和输送系统创造了独特的药理动力学和临床特征,使得个性化ADHD治疗成为可能.
  • 传统上,长效兴奋剂选项需要在早上服用.

研究的目的:

  • 评估延迟释放和延长释放甲基化物 (DR/ER-MPH) 的特性和临床效用.
  • 为临床医生提供关于在儿童和成人多动症患者群体中使用DR/ER-MPH的实际指导.
  • 将DR/ER-MPH置于ADHD药物治疗的更广泛的环境中.

主要方法:

  • 对现有临床数据的审查.
  • 对现实世界的证据和新兴研究进行分析.
  • 纳入专家的临床经验.

主要成果:

  • DR/ER-MPH是第一个用于晚上服用的长效兴奋剂.
  • 这种配方在早上醒来时提供了延迟的临床效果,这是刺激疗法的范式转变.
  • DR/ER-MPH独特的药理动力学特征使得需要针对ADHD进行量身定制的临床治疗.

结论:

  • DR/ER-MPH为管理ADHD提供了一种新的治疗选择,与传统的早晨剂量的兴奋剂不同.
  • 了解它的特征对于优化儿童,青少年和成人治疗策略至关重要.
  • 进一步的现实数据和临床经验将完善这种创新的ADHD药物的应用.