删除SETDB1导致DNA脱甲基化和多个指基因的上调

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Updated: Jun 23, 2025

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Yong-Kook Kang1,2, Jaemin Eom3,4, Byungkuk Min3

  • 1Development and Differentiation Research Center, Aging Convergence Research Center (ACRC), Korea Research Institute of Bioscience Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, South Korea. ykkang@kribb.re.kr.

Molecular biology reports
|June 21, 2024
PubMed
概括

SETDB1 (SET域分叉-1) 抑制了C2H2-指蛋白 (C2H2-ZFP) 基因,影响了细胞身份. SETDB1-null细胞显示这些ZFP基因的低甲基化和上调,特别是19号染色体上的集群.

关键词:
通过DNA甲基化.过甲基化过度的发生.低甲基化是一种低甲基化.在SETDB1中,我们可以使用SETDB1.指蛋白质是一种指蛋白质.

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