大麻,烟草使用和COVID-19的结果
Nicholas B Griffith1, Timothy B Baker2, Brendan T Heiden3,4
1Washington University School of Medicine, St Louis, Missouri.
JAMA network open
|June 21, 2024
概括
大麻使用与COVID-19患者住院和ICU入院的风险更高,独立于烟草使用和其他因素. 这突出了大麻作为严重的COVID-19结果的潜在风险因素.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 药物使用研究研究 药物使用研究
背景情况:
- 大麻使用和COVID-19严重程度之间的关联仍然不清楚,特别是考虑到烟草使用等混因素时.
- 了解物质使用对COVID-19结果的影响对于公共卫生战略至关重要.
研究的目的:
- 研究目前大麻使用和烟草吸烟与被诊断为COVID-19的患者不良健康结果之间的关联.
- 为了确定大麻使用是否是COVID-19并发症的独立风险因素,控制已知的风险因素.
主要方法:
- 从2020年2月到2022年1月使用电子健康记录数据的回顾性队列研究.
- 包括72,501名COVID-19患者,分析当前的大麻使用和烟草吸烟作为暴露.
- 多变量建模评估了物质使用与住院治疗,ICU入院和全因死亡率等结果之间的关联,并对共变量进行了调整.
主要成果:
- 目前的烟草吸烟与住院,ICU入院和全因死亡率的风险增加显著相关.
- 目前的大麻使用显示出与增加住院和ICU入院风险的显著关联.
- 大麻使用与全因死亡率没有显著的关联,但表明风险增加的趋势.
结论:
- 大麻使用似乎是COVID-19相关住院和重症监护室入院的独立风险因素.
- 研究结果表明,医疗保健提供者在评估COVID-19风险和患者管理时应考虑使用大麻.
- 需要进一步的研究来阐明大麻对COVID-19结果的影响背后的机制.
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