维生素B9和B12在患有注意力缺陷多动障碍 (ADHD) 的儿童中
Fatemeh Razavinia1, Atefeh Ebrahimiyan1, Shahla Faal Siahkal2
1Midwifery Department, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
概括
患有注意力缺陷多动症 (ADHD) 的儿童的维生素B9和维生素B12水平较低. 这一系统性审查强调了儿童群体中ADHD与潜在的营养联系.
科学领域:
- 神经科学是一个神经科学.
- 儿科 儿科 儿科
- 营养精神病学 营养精神病学
背景情况:
- 注意缺陷多动症 (ADHD) 是儿童中普遍存在的一种神经发育障碍.
- 维生素B组对细胞代谢,神经递质合成和核酸生产至关重要.
- 由于它们的代谢作用,研究ADHD儿童的维生素B9和B12水平至关重要.
研究的目的:
- 系统地调查和比较被诊断患有ADHD的儿童与健康儿童的维生素B9和维生素B12的血水平.
- 通过元分析,综合现有病例控制和横截面研究的发现.
主要方法:
- 在多个电子数据库 (科学网,MEDLINE,EMBASE,Scopus,伊朗MEDEX,Cochran,SID) 进行系统的文献搜索,截至2023年6月.
- 包括全文病例对照或横截面研究,重点关注有或没有ADHD的6-12岁儿童.
- 使用Review Manager软件 (RevMan 5.4) 进行的元分析,以95%的置信区间 (CI) 计算标准化平均差异 (SMD);使用灵敏度分析来解决异质性.
主要成果:
- 六项包括982名儿童 (204名女孩,744名男孩) 的研究被纳入了分析.
- 在患有多动症的儿童中观察到显著较低的维生素B9水平 (SMD -0.80,95% CI [-1.55, -0.04]).
- 在患有多动症的儿童中,维生素B12水平显著降低 (SMD -0.29,95% CI [-0.42, -0.16]),在敏感性分析后,异质性降至21% (SMD -0.19,95% CI [-0.34, -0.04]).
结论:
- 这一系统性审查和元分析表明,与健康同龄人相比,多动症儿童的维生素B9和维生素B12的血水平显著降低.
- 这些发现表明,这些B族维生素缺乏与儿童ADHD的病理生理学或表现之间存在潜在的关联.
- 对维生素补充对ADHD管理的治疗影响进行进一步的研究是有必要的.
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