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相关概念视频

The Blood-brain Barrier00:49

The Blood-brain Barrier

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相关实验视频

Updated: Apr 6, 2026

A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
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A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

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作为微泡辅助血脑屏障开放的发射器的CMUT.

M Sait Kilinc, Reza Pakdaman Zangabad, Costas Arvanitis

    IEEE transactions on ultrasonics, ferroelectrics, and frequency control
    |June 21, 2024
    PubMed
    概括

    电容微机超声波传感器 (CMUT) 现在可以传输聚焦超声波 (FUS) 进行血脑屏障 (BBB) 开放. 一种新的多相调制 (PM) 技术有效地隔离了微泡信号,为FUS应用实现了CMUT.

    科学领域:

    • 生物医学工程 生物医学工程
    • 声学物理 声学物理
    • 神经科学是一个神经科学.

    背景情况:

    • 使用微气泡 (MB) 的聚焦超声波 (FUS) 是打开血脑屏障 (BBB) 的关键策略,以改善药物输送.
    • 目前的FUS系统使用压电式传感器,但电容微加工超声波传感器 (CMUT) 具有作为宽带替代品的潜力.
    • 在FUS频率下,CMUT的非线性行为和低压输出限制了它们作为BBB开放的发射器的使用.

    研究的目的:

    • 调查使用CMUT作为FUS介导BBB打开的发射器的可行性.
    • 开发和验证一种方法来减轻CMUT非线性,并为BBB打开应用程序隔离MB信号.

    主要方法:

    • 建议使用多相调制 (PM) 来隔离CMUT发射器的MB辐射.
    • 计算了人类尺寸的FUS系统所需的压力水平 (在150mm焦距下10kPa峰值负压).
    • 经过实验验证的CMUT压力生成和PM信号处理在自由场,横测量和用Definity MBs进行体外管幻影.

    主要成果:

    • 计算证实,10kPa的PNP足以激发MB.
    • 随时可用的CMUT可以在400-800 kHz时产生所需的压力水平.
    • PM实现了超过50dB的基本波信号抑制.

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    Monitoring Blood-Brain Barrier Opening in Rats with a Preclinical Focused Ultrasound System
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    Last Updated: Apr 6, 2026

    A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents
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    A High-Throughput Image-Guided Stereotactic Neuronavigation and Focused Ultrasound System for Blood-Brain Barrier Opening in Rodents

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    Real-Time Intravital Multiphoton Microscopy to Visualize Focused Ultrasound and Microbubble Treatments to Increase Blood-Brain Barrier Permeability
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    Monitoring Blood-Brain Barrier Opening in Rats with a Preclinical Focused Ultrasound System
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  • 在体外测试表明,MB波检测的非线性信号隔离和信号对噪声比 (SNR) 是足够的.

    • 结论:

    • 多相调制有效地减轻了CMUT对FUS BBB打开的波生成.
    • CMUT可以作为FUS应用的发射器,扩大其潜力.
    • 这项工作为宽带传输和接收在FUS介导的BBB开放中为临床和临床前使用开辟了新的机会.