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Updated: Jun 11, 2026

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在化治疗肝细胞中,SDF-1/CXCR4和相关炎症因子的表达

Rui Yang1,2, Hongting Shen2, Mingjun Wang2

  • 1Department of Public Health, Medical College, Qinghai University, Xi'ning, China.

PloS one
|June 21, 2024
PubMed
概括

过多的化物暴露会通过激活SDF-1/CXCR4信号通路,引发肝炎. 这种途径增加了诸如核因子-κB (NF-κB),介质素-6 (IL-6),瘤缩因子-α (TNF-α) 和介质素1β (IL-1β) 等炎症因素,从而导致肝损伤.

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相关概念视频

NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The heterodimer of NF-κB...