长时间禁食后的葡萄糖负荷增加了糖尿病并发症患者的氧化应激相关反应
Ekaterina von Rauchhaupt1,2, Claus Rodemer1, Elisabeth Kliemank1,2
1Department of Endocrinology, Diabetology, Metabolic Diseases and Clinical Chemistry (Internal Medicine I), University Hospital of Heidelberg, Heidelberg, Germany.
患有2型糖尿病和并发症的人在禁食和葡萄糖负载后对氧化应激的抵抗力降低. 这突出了潜在的风险,并为糖尿病管理的饮食干预提供了信息.
科学领域:
- 代谢健康 代谢健康
- 糖尿病研究 糖尿病研究
- 细胞生物学 细胞生物学
背景情况:
- 2型糖尿病 (T2D) 涉及长时间的代谢状态,过多的基质流量和高血糖,损害了代谢灵活性和抗氧化能力.
- 禁食后对葡萄糖挑战的细胞反应对于理解T2D病理生理学和并发症至关重要.
研究的目的:
- 调查T2D患者,糖尿病并发症或没有糖尿病并发症的长期禁食模仿饮食后对葡萄糖负荷的细胞反应.
- 评估禁食和葡萄糖挑战对外周血液单核细胞 (PBMCs) 氧化应激和二碳抗性的影响.
主要方法:
- 口服葡萄糖耐受性测试在5天的禁食模仿饮食之前和之后在耐葡萄糖对照 (CON),没有并发症的T2D (T2D-),并有并发症的T2D (T2D+) 中进行.
- 测量了PBMC对甲基酸盐 (MG) 的耐药性,同时对二碳酸盐排毒,氧化应激标志物和线粒体生物发生的定量PCR分析进行了测量.
- 线粒体复合蛋白表达通过西式涂抹进行评估.
主要成果:
- 患有T2D和并发症 (T2D+) 的个体显示PBMC抵抗MG禁食后和葡萄糖负载下降,与T2D和CON组不同.
- T2D+表现出涉及二碳酸排毒,氧化应激和线粒体复合体V的基因的高表达,表明细胞应激增加.
- 虽然线粒体数量保持不变,但线粒体生物发生率在T2D-与CON相比增加,T2D-在禁食后显示抗氧化剂防御增加.
结论:
- 患有T2D和糖尿病并发症的个体在长时间禁食后表现出对葡萄糖诱导的氧化应激的敏感性增加.
- 研究结果表明,细胞对禁食和葡萄糖负载的反应因糖尿病并发症状况而异.
- 这项研究可能有助于开发针对性饮食干预措施,以控制2型糖尿病.
更多相关视频
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
08:30Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
Published on: March 15, 2018
相关概念视频
Diabetes: Symptoms, Diagnosis, and Complications
Glucose Homeostasis: Regulation of Blood Glucose
During fasting, when blood glucose levels are low, the pancreas secretes glucagon. it...
Hypoglycemia and Glucagon
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
Metabolic States of the Body: The Postabsorptive State
Initially, glycogen stored in the liver is broken down to release glucose into the bloodstream, while glycogen in the muscles is broken down to supply glucose for energy directly within the muscle cells. As glycogen stores diminish,...
Hormones Regulating Blood Glucose
In addition to accelerating glucose uptake and utilization, insulin has...
