PHD2酶是一种细胞内传感器,可以启动对高的恒常反应

Kerem C Gurol1, Thomas Jursa2, Eun Jeong Cho3

  • 1Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712.

概括

哺乳动物细胞感知高 (Mn) 水平,因为Mn通过取代铁来抑制prolyl氧化酶域 (PHD) 酶. 这一发现揭示了平衡的基本机制.

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