饮食因素和肌缩性侧面硬化症的风险:一个两样本的门德尔随机化研究
Zhaoyi Jing1, Xianghua Qi2, Jing Teng1
1Shandong University of Traditional Chinese Medicine, Jinan, China.
Medicine
|June 21, 2024
概括
这项研究调查了饮食和肌缩性侧面硬化症 (ALS) 之间的因果关系. 研究结果表明,食用油性鱼,咖啡和新鲜水果可能会降低ALS风险,为营养预防策略提供了洞察力.
科学领域:
- 营养流行病学 营养流行病学
- 神经退行性疾病 神经退行性疾病
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究表明,饮食因素会影响肌缩性侧面硬化症 (ALS) 风险.
- 饮食和ALS之间的因果关系需要使用可靠的方法进一步调查.
- 建立ALS预防的营养指南需要了解饮食-ALS因果关系.
研究的目的:
- 采用门德尔的随机化来探索各种饮食因素与ALS之间的因果关系.
- 确定特定的饮食成分,可能对ALS风险产生因果影响.
- 为潜在的ALS预防营养干预提供基于证据的见解.
主要方法:
- 利用来自IEU开放GWAS项目的大型遗传数据集.
- 应用了多种门德尔随机化方法,包括反变量加权,加权中位数和MR-Egger.
- 进行异质性和性分析,以确保因果推理的有效性.
主要成果:
- 基因预测的油性鱼类摄入量与降低ALS风险存在因果关系 (OR:0.7648,P=0.0420).
- 咖啡摄入量与患ALS的风险降低有因果关系 (OR:0.7385,P=0.0256).
- 新鲜水果摄入量与较低的ALS风险有显著的因果关系 (OR:0.6165,P=0.0278).
结论:
- 油性鱼类,咖啡和新鲜水果的摄入因果相关,与减少肌缩性侧面硬化症的风险有关.
- 对于其他调查的饮食因素 (例如,加工肉,面包,其他蔬菜) 没有发现显著的因果关系.
- 这些发现支持特定饮食选择在减轻ALS风险方面的潜在作用,为未来的营养建议提供信息.
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