抗胆固醇和镇静剂负担对艾滋病毒感染者的认知影响
Henry Ukachukwu Michael1,2, Marie-Josée Brouillette3,4,5, Robyn Tamblyn1,6
1Division of Experimental Medicine, McGill University.
AIDS (London, England)
|June 21, 2024
概括
高抗胆固醇和镇静剂药物负担与艾滋病毒感染成人认知功能恶化和自我报告的认知困难有关. 个性化药物管理可能有助于减少这些不良影响.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 认知障碍是中年和老年艾滋病毒感染者的重要关注点.
- 抗胆固醇和镇静药物是常用的,可能会对认知产生负面影响.
研究的目的:
- 研究抗胆固醇和镇静剂药物负担与艾滋病毒成人的认知能力之间的关联.
- 检查药物负担和自我报告的认知困难 (SCD) 之间的关系.
主要方法:
- 从正面大脑健康现在 (BHN) 研究的数据的横截面分析.
- 使用简要认知能力测量 (B-CAM) 评估认知能力.
- 通过感知缺陷问卷 (PDQ) 测量的自我报告的认知困难.
- 使用ACB,ACSBC,ADS,ARS和SLM评分系统量化药物负担.
- 使用了多变量回归分析.
主要成果:
- 高抗胆固醇负担与较差的认知能力 (β = -3.81) 和增加的SCD (β = 3.89) 相相关.
- 使用三种或更多的抗胆固醇药物导致认知能力恶化 (β = -4.45).
- 使用三种或更多的镇静剂增加了SCD (β = 4.35).
- 负面关联在认知能力较低,难度较高的个体中更强.
结论:
- 抗胆固醇和镇静药物的负担可能会导致艾滋病毒感染者的认知障碍.
- 建议进行个性化药物管理和定期认知评估,以减轻不良影响.
更多相关视频
07:02A Computerized Test Battery to Study Pharmacodynamic Effects on the Central Nervous System of Cholinergic Drugs in Early Phase Drug Development
Published on: February 11, 2019
9.8K
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
16.6K
相关概念视频
01:27CNS Depressants: Alcohol and Nicotine
202
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
202
01:17Sedatives and Hypnotics Drugs: Miscellaneous Agents
168
Sedatives and hypnotics encompass a wide range of substances, each with its unique mechanism of action, uses, and potential adverse effects.
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
168
01:30Negative and Cognitive Symptoms of Schizophrenia
48
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
48
01:28Depressants
107
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
107
01:29Pulmonary Tuberculosis I
231
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
231
01:30Indirect-Acting Cholinergic Agonists: Pharmacological Actions
659
Indirect-acting cholinergic agonists, also known as anticholinesterases, exert their pharmacological effects by enhancing cholinergic transmission in various body parts, including the neuromuscular junction, autonomic cholinergic synapses, and the brain.
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
659