丸激素替代疗法用于男性阴性腺的治疗
Joel J Heidelbaugh1, Aleksandr Belakovskiy1
1University of Michigan Medical School, Ann Arbor, Michigan.
American family physician
|June 21, 2024
概括
替代疗法可以改善诸如低骨密度和瘦肉质等低阴性腺症的症状. 最近的试验表明它不会增加心血管风险,支持对符合条件的男性进行考虑.
科学领域:
- 内分泌学 在内分泌学.
- 男人的健康 男人的健康
- 临床医学 临床医学
背景情况:
- 缺乏症 (催眠症) 定义为血清的低水平和相关症状.
- 替代疗法 (TRT) 的潜在好处包括改善性功能,情绪,骨密度和瘦体质量.
- 关于TRT对心血管事件和死亡率的影响存在相互矛盾的证据.
研究的目的:
- 审查当前对缺乏症及其管理的理解.
- 评估替代疗法的益处和风险,特别是心血管安全.
- 提供关于在符合条件的男性中启动和监测TRT的指导.
主要方法:
- 对现有研究的审查以及对替代疗法的大型随机试验.
- 关于TRT对性功能,情绪,身体组成和心血管结果的影响的证据分析.
- 在选择治疗和监测协议时考虑以患者为中心的因素.
主要成果:
- TRT可以改善性功能,抑郁症状,骨密度和瘦体质量.
- 一项大型随机试验表明,即使在高风险患者中,TRT也没有增加心肌梗塞或中风的风险.
- 以前对TRT增加心血管风险的担忧没有得到最近的大规模证据的支持.
结论:
- 在关于益处和风险的共同决策后,应考虑对缺乏症的男性进行替代疗法.
- 选择治疗需要考虑患者的偏好,药理动力学,副作用和成本.
- 定期监测症状,不良反应,坚持和特定的实验室参数 (,血红素,PSA) 对于接受TRT的男性至关重要.
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