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养殖的营养补充可以通过生长激素-胰岛素类似的生长因子轴促进胚胎发育

Guoxia Wang¹, Haochu Deng¹, Taiping Wang¹

¹College of Animal Science and Technology, Jilin Agricultural University, Changchun 130118, China.

Poultry science

|June 21, 2024

概括

母亲补充β-胡卜素可以通过促进生长激素和胰岛素类生长因子-1信号通路来增强胚胎肝脏的发育. 这种营养策略促进后代的生长和新陈代谢.

科学领域:

动物营养动物营养
发展生物学发展生物学
分子内分泌学分子内分泌学

背景情况:

胚胎发育需要显著的营养供应器官生成.
母亲的营养极大地影响后代的生长,发育和新陈代谢.
β-胡卜素是一种重要的营养素,在发育过程中具有潜在的作用.

研究的目的:

为了研究母亲的食β-胡卜素补充剂对胚胎发育的影响.
阐明β-胡卜素对肝脏发育的影响背后的分子机制.
探索生长激素-胰岛素类生长因子-1轴在调解这些效应中的作用.

主要方法:

用两剂β-胡卜素 (120毫克/公斤和240毫克/公斤) 补充产母的饮食.
血清生物标志物的分析,包括肝指数,生长激素 (GH),胰岛素样生长因子-1 (IGF-1) 和肝细胞生长因子 (HGF).
通过转录组测序评估肝脏基因和蛋白质表达,包括GH/生长激素受体 (GHR),IGF-1 mRNA和增殖细胞核抗原 (PCNA).

主要成果:

母亲的β-胡卜素显著增加了胚胎中的血清GH,IGF-1和HGF水平.
肝脏表达GH/GHR,IGF-1mRNA和PCNA蛋白质的高调.
转录组分析显示,肝脏中细胞增殖和代谢途径的丰富.

结论:

母亲补充β-胡卜素可以促进胚胎肝脏的发育.
GH-IGF-1轴是β-胡卜素对胚胎生长的影响的关键调解者.
食β-胡卜素可以成为优化家禽养策略以改善后代发育的宝贵工具.

关键词:

的胚胎的胚胎增长激素-胰岛素类似的增长因子肝脏的发育肝脏的发育代谢代谢代谢代谢乙-胡卜素 β-胡卜素的含量

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