一个新的风险评分系统使用cox比例危险机器学习方法预测肝细胞癌的整体存活率
Haibei Xin1, Yuanfeng Li2, Quanlei Wang3
1Department of Hepatobiliary Surgery, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, PR China.
Computers in biology and medicine
|June 21, 2024
概括
一个基于CoxPH的新模型准确地预测了手术后肝细胞癌 (HCC) 患者的存活率和复发率. 这个工具有助于个性化治疗和随访策略的HCC.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物信息学是一种生物信息学.
背景情况:
- 肝细胞癌 (HCC) 预后预测对于个性化医学至关重要.
- 开发可靠的HCC患者结果模型是一个关键的挑战.
研究的目的:
- 开发和验证HCC患者的实际预后预测模型.
- 为了确定与免疫相关的生物标志物来预测HCC患者的存活率.
主要方法:
- 在发现和验证队列中招募了222名HCC患者.
- 使用mIHC.量化免疫相关蛋白质表达 (CD8,CD68,CD163,PD-1,PD-L1) 的研究.
- 构建并评估了五种机器学习模型,包括CoxPH,用于预测预后.
主要成果:
- 确定了19个与生存相关的特征,包括CD68+和CD8+细胞透.
- 考克斯PH模型表现出优异的性能 (AUC 0.839,C指数 0.779).
- 该模型在两个队列中准确预测了整体生存率和复发风险,AUC>0.75的生存率.
结论:
- 一个基于CoxPH的新型风险评分系统有效地预测了手术后的HCC存活率和复发率.
- 该模型整合了临床,实验室和免疫相关特征,以实现高预测准确度.
- 这些发现可以优化HCC患者的临床随访和治疗干预措施.
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