系统性利多卡因与勃起器脊柱平面阻断用于改善腹腔镜胆囊切除术后的恢复质量:一个随机对照试验
Zhiwei Lin1, Chanjuan Chen2, Shengyuan Xie3
1Department of Anesthesiology, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Journal of clinical anesthesia
|June 21, 2024
概括
静脉注射利多卡因在腹腔镜胆囊切除术后提供与勃起器脊柱平面阻塞 (ESPB) 相似的恢复质量. 这项研究发现,利多卡因与ESPB无差,为多模式止痛提供了切实可行的替代方案.
科学领域:
- 麻醉学 麻醉学
- 术后恢复 术后恢复
- 疼痛管理 疼痛管理
背景情况:
- laparoscopic胆囊切除术的恢复可以通过有效的止痛药来改善.
- 勃起器脊柱平面阻塞 (ESPB) 和静脉注射利多卡因是术后疼痛控制的潜在选择.
研究的目的:
- 为了比较腹腔镜胆囊切除术后静脉注射利多卡因,ESPB和安慰剂之间的恢复质量和镇痛.
- 为了评估与ESPB相比,利多卡因的非劣等性.
主要方法:
- 一项前性,三臂,双盲,随机,安慰剂控制的非劣势性试验,涉及126名接受腹腔镜胆囊切除术的成年患者.
- 干预措施包括静脉注射利多卡因输液,双边ESPB与罗皮瓦卡因,或双边ESPB与盐水.
- 主要结局是24小时术后恢复质量-15 (QoR-15) 评分.
主要成果:
- 静脉注射利多卡因在24小时QOR-15得分方面与ESPB不劣 (中位数差异为-1).
- 与安慰剂相比,利多卡因和ESPB都显著改善了恢复,降低了疼痛评分和吗啡消耗.
- 在利多卡因和ESPB之间没有观察到恢复或疼痛的显著差异,副作用最小.
结论:
- 静脉注射利多卡因在腹腔镜胆囊切除术中提供了与ESPB相比的不劣质的恢复质量.
- 利多卡因为多模式止痛提供了一种实用且易于获得的替代方案,避免需要专门的区域麻醉技术.
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