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Updated: Jun 23, 2025

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics
06:00

Through the Looking Glass: Time-lapse Microscopy and Longitudinal Tracking of Single Cells to Study Anti-cancer Therapeutics

Published on: May 14, 2016

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针对CDK9的PROTAC L055抑制了ERα阳性乳腺癌

Wenmin Chen1, Yue Wu2, Chuanyu Yang3

  • 1Yunnan Key Laboratory of Animal Models and Human Disease Mechanisms, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China; Kunming College of Life Sciences, University of Chinese Academy Sciences, Kunming 650204, China; Department of Basic Medical Sciences, Beihai Vocational College of Wellness, Beihai 536000, China.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
|June 21, 2024
PubMed
概括

一种新型的向蛋白质分解的嵌合体 (PROTAC),L055,在ERα阳性乳腺癌细胞中有效降解CDK9. 这种有针对性的方法在治疗乳腺癌和其他恶性瘤方面表现有前途.

关键词:
编号:CRBN 编号:CRBN 编号:CRBN 编号:CRBN 编号:CRBN 编号:CRBN 编号:CRBN循环林依赖性激酶9的作用.有ERα阳性的乳腺癌.针对蛋白质溶解的嵌合体.

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