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基于与癌症免疫治疗结果相关的肠道微生物群的生态拓

Lisa Derosa¹, Valerio Iebba², Carolina Alves Costa Silva³

¹Gustave Roussy Cancer Campus, ClinicObiome, Villejuif, France; Université Paris-Saclay, Ile-de-France, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U1015, Equipe Labellisée-Ligue Nationale contre le Cancer, Villejuif, France; Department of Medical Oncology, Gustave Roussy, Villejuif, France.

|June 21, 2024

概括

研究人员开发了一种新的评分系统,用于评估接受免疫检查点抑制剂 (ICI) 的癌症患者的肠道失调. 这种工具有助于预测治疗反应,并指导个性化微生物群干预,以获得更好的结果.

科学领域:

癌症学
微生物组研究
免疫疗法

背景情况:

肠道微生物群显著影响癌症患者对免疫检查点抑制剂 (ICI) 的反应.
对于有害的肠道功能障碍的标准定义仍然难以捉摸.
了解这些微生物的影响对于优化癌症治疗至关重要.

研究的目的:

在癌症患者中定义和量化与ICI反应相关的肠道失调.
开发基于肠道微生物组成的ICI治疗结果预测工具.
建立个性化,以微生物群为中心的治疗策略的基础.

主要方法:

来自245名非小细胞肺癌 (NSCLC) 患者的便样本的基因组测序.
构建物种层面的共同繁多网络,并将其分为物种互动组 (SIG).
开发和验证包括Akkermansia物种量化的拓评分 (TOPOSCORE),在多种癌症群中进行测试 (NSCLC,泌尿器,结肠直肠癌,黑色素瘤).

主要成果:

分别确定了37种和45种与ICI耐药性 (SIG1) 和反应 (SIG2) 相关的转基因物种 (MGS).
由微生物网络拓和Akkermansia丰富度得出的TOPOSCORE在独立的NSCLC和生殖尿路癌症队列中显示出预测价值.
使用21个细菌探针的基于qPCR的评分系统在NSCLC,结肠直肠癌和黑色素瘤患者中被成功验证.

结论:

开发的TOPOSCORE作为评估肠道失调的动态诊断工具.
这种方法可以指导个性化以微生物群为中心的干预措施,从而提高ICI的有效性.
这些发现突显了肠道微生物在癌症免疫治疗反应中的关键作用.

关键词:

阿克尔曼西亚时间: 时间:标签: 美国生物标志物癌症肠道微生物群免疫检查点封锁免疫疗法基因组学微生物组

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