一个可 perfusable,血管化的脏器官在芯片上的模型
Katharina T Kroll1,2,3, Kimberly A Homan3, Sebastien G M Uzel1,2
1Harvard University, Paulson School of Engineering and Applied Sciences, Cambridge, MA, United States of America.
Biofabrication
|June 21, 2024
概括
研究人员开发了一种可输注脏器官在芯片上的模型,模仿本地组织微环境. 这一突破使控制的输液成为可能,促进药物测试和器官的治疗应用.
科学领域:
- 生物医学工程 生物医学工程
- 再生医学是一种再生医学.
- 有机物技术 有机物技术
背景情况:
- 对器官的可控输液对于复制本土组织微环境至关重要.
- 现有的模型缺乏用于药物测试和治疗等先进应用所必需的血管整合.
研究的目的:
- 开发一种可 perfusable,血管化的脏器官在芯片上的模型.
- 为了实现微型 - 大型血管的整合,以增强脏器官功能.
主要方法:
- 在细胞外基质 (ECM) 中构建了一个带有两个通道的芯片,其中一个与脏器官和另一个与内皮细胞播种,以形成一个巨型血管.
- 利用内源性内皮细胞迁移和光线对光线的解剖形成来实现微型-宏观血管的整合.
- 引入了光标记的德克斯和红细胞,以评估通过集成血管网络的输液.
主要成果:
- 成功创建了一个可输注脏器官在芯片上的模型,集成了微型和宏观血管.
- 证明了内皮细胞从有机体向大血管的成功迁移,形成功能性解剖.
- 通过有机体的微血管网络确认了德克斯和红细胞的运输,到达质表皮.
结论:
- 开发的模型可以控制脏器官的输液,密切模仿本地组织血管化.
- 这种方法为改进药物测试和潜在的治疗应用提供了一个平台.
- 该方法为创建其他透的人类器官系统提供了一条途径.
关键词:
这是一种解剖解剖学.脏有机物 脏有机物脏在芯片上的模型perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion 这是一个非常重要的方法,它可以让一个人觉得自己是一个非常重要的东西,而不是一个非常重要的东西,而不是一个非常重要的东西,而是一个非常重要的东西.血管化的血管化.相关概念视频
Kidney Structure
The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.
External Anatomy of the Kidney
The kidneys are a pair of bean-shaped organs in the human body that play a critical role in maintaining overall health. They filter out waste products from the blood, regulate blood pressure, maintain electrolyte balance, and stimulate the production of red blood cells.
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
The kidneys are located in the retroperitoneal space on either side of the vertebral column, protected posteriorly by the 11th and 12th ribs. The right kidney sits slightly lower than the left owing to the presence of the liver...
Internal Anatomy of the Kidney
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Renal Corpuscle
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...


