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Updated: Jun 23, 2025

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由IL-18和循环二核酸cGAMP编排的代谢开关编程了肠道耐受性

Randall T Mertens1, Aditya Misra2, Peng Xiao3

  • 1Gene Lay Institute of Immunology and Inflammation, Brigham and Women's Hospital, Mass General Hospital, and Harvard Medical School, Boston, MA 02115, USA; Ann Romney Center for Neurologic Diseases, Harvard Medical School and Brigham and Women's Hospital, Boston, MA 02115, USA; Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA 02115, USA.

Immunity
|June 21, 2024
PubMed
概括

这项研究揭示了一种先天的免疫代谢开关,通过重编程巨细胞来促进长期的肠道耐受性. 这种由互白素-18 (IL-18) 驱动的开关,将新陈代谢转移到脂肪酸氧化 (FAO),增强免疫记忆和肠道耐受性.

关键词:
在IL-18中,IL-18是最重要的.在 SLC12A3 中.两个可变电路的可变电路.cGAMPP 的情况.脂肪酸氧化过程中的脂肪酸氧化.免疫代谢的免疫代谢.肠道耐受性 肠道耐受性巨细胞是一个巨细胞.代谢重编程是指代谢重编程.代谢开关是代谢开关.

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