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免疫检查点抑制剂生物标志物的进展和前景

Hirohito Yamaguchi¹, Jung-Mao Hsu², Linlin Sun³

¹Graduate Institute of Cell Biology, China Medical University, Taichung City 406040, Taiwan; Graduate Institute of Biomedical Sciences and Institute of Biochemistry and Molecular Biology, China Medical University, Taichung City 406040, Taiwan; Cancer Biology and Precision Therapeutics Center and Research Center for Cancer Biology, China Medical University, Taichung City 40402, Taiwan.

Cell reports. Medicine

|June 21, 2024

概括

识别生物标志物对于有效的免疫检查点抑制剂 (ICI) 癌症治疗至关重要. 本综述详细介绍了既定和新兴的生物标志物,以改善ICI治疗的患者选择和治疗结果.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
生物标志物研究生物标志物研究

背景情况:

免疫检查点抑制剂 (ICI) 通过向PD-1和CTLA-4等分子来利用抗癌免疫力.
虽然ICI提供了持久的反应,但挑战包括低响应率,严重的副作用和高成本,需要更好的患者选择.

研究的目的:

为ICI治疗提供预测生物标志物的最新审查.
讨论当前的挑战,并探索ICI生物标志物发现的未来方向.

主要方法:

对ICI治疗的既定和新兴生物标志物的文献综述.
综合当前关于生物标志物的知识,包括PD-L1表达,MSI,TMB和免疫细胞透.

主要成果:

已确定的生物标志物包括瘤PD-L1表达,DNA不匹配修复缺陷,微卫星不稳定性高,以及瘤突变负担.
研究中的新兴生物标志物包括瘤透的淋巴细胞,外围淋巴细胞,肠道微生物群以及与DNA损伤和抗原呈现相关的途径.

结论:

生物标志物识别对于优化ICI疗效和患者选择至关重要.
对新型生物标志物的进一步研究对于克服ICI治疗局限性和改善患者治疗结果至关重要.

关键词:

DNA损伤修复缺陷缺陷修复缺陷在PD-L1中.抗原呈现的呈现方式.生物标志物生物标志物同抑制性受体的共抑制性受体缺陷的不匹配修复缺陷的不匹配修复葡萄糖酶化是什么? 葡萄糖酶化是什么?免疫检查点抑制剂免疫检查点抑制剂免疫组织化学染色微生物组是一个微生物组.微卫星的不稳定性高微卫星的不稳定性高血生物标志物血生物标志物瘤基因突变负担瘤透或外围T细胞.

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