学习和记忆的神经关联因早期生活中的压力而改变
Jeniffer Sanguino-Gómez1, Stefan Huijgens1, Maxine den Hartog1
1Brain Plasticity Group, SILS-CNS, University of Amsterdam, Amsterdam, The Netherlands.
Neurobiology of learning and memory
|June 21, 2024
概括
早期的生活压力通过改变海马和杏仁体中的神经元激活模式,损害了小鼠的恐惧学习和记忆检索. 这些影响持续到成年期,可能涉及被破坏的恩格拉姆细胞分配.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 分子生物学分子生物学
背景情况:
- 早期生活压力 (ELS) 对学习和记忆有负面影响,但潜在的机制尚不清楚.
- 在早期发育期间,母亲的护理质量会影响长期的行为适应.
- 像c-Fos和Arc这样的直接早期基因 (IEG) 对记忆形成和检索至关重要.
研究的目的:
- 研究生命早期压力 (ELS) 如何影响雄性小鼠的记忆和神经元激活.
- 在恐惧调节后,检查c-Fos和Arc表达在牙状回环 (DG) 和底侧杏仁体 (BLA) 中的作用.
- 评估RU38486 (RU486) 是否可以抵消ELS引起的记忆缺陷.
主要方法:
- 雄性Arc::dVenus记者小鼠通过有限的床铺/筑巢材料 (PND 2-9) 经历了ELS.
- 动物在成年时经历了恐惧调节和记忆检索任务.
- 在DG和BLA中c-Fos和Arc::dVenus+细胞的表达在训练后和检索后得到量化.
主要成果:
- ELS减少了恐惧的获取和上下文记忆的检索.
- 在DG和BLA培训后,ELS减少了Arc::dVenus+细胞;c-Fos+细胞没有受到影响.
- 在检索后,ELS减少了腹部DG和BLA中的c-Fos+细胞,改变了c-Fos/Arc的同位分.
结论:
- 在恐惧记忆的获取和检索过程中,ELS会改变神经元激活模式.
- 这些变化可能是ELS对恐惧记忆处理的持久影响的基础.
- 腹部DG中受损的恩格拉姆细胞分配可能会导致ELS诱导的记忆缺陷.
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