粗颗粒物空气污染和多药耐药结核病队列中的死亡率
Huiying Feng1, Erjia Ge2, Nicholas Grubic2
1Center for Tuberculosis Control of Guangdong Province, Guangzhou, China.
The Science of the total environment
|June 21, 2024
概括
长期暴露于粗颗粒物 (PM2.5-10) 显著增加了多药耐药结核病 (MDR-TB) 患者的死亡风险. 温度和湿度改变了这些风险,突出了对空气污染监测的必要性.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 结核病研究 结核病研究
背景情况:
- 环境粗颗粒物 (PM2.5-10) 对多药耐药结核病 (MDR-TB) 患者死亡率的影响尚未研究.
- 温度和湿度在这种关联中的改变作用是未知的.
研究的目的:
- 评估长期暴露于PM2.5-10对MDR-TB患者死亡率的影响.
- 研究温度和湿度对这种关联的改变作用.
主要方法:
- 对3469名MDR-TB患者的队列进行了死亡率跟踪.
- 考克斯的比例危险模型被用来估计与PM2.5-10相关的死亡风险,考虑到温度和湿度.
- 使用光滑的线条分析了暴露-反应关系.
主要成果:
- 在各种温度和湿度条件下,PM2.5-10暴露与MDR-TB患者全因死亡率的增加有关.
- 温度和湿度在不同的人口和环境因素中表现出异质的改变效应.
- 非线性暴露-反应曲线表明,从大约15μg/m3开始的PM2.5-10暴露的累积风险约为15μg/m3.
结论:
- 长期暴露于PM2.5-10会显著损害MDR-TB患者,其影响由温度和湿度调节.
- 对于PM2.5-10的紧急监测是必要的,以减少MDR-TB的严重程度,特别是与空气污染和恶劣天气的同时暴露.
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