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对携带blaNDM-1细菌的分布特征和水平基因转移元素的全面分析

Shijie Yao¹, Jiaqin Yu¹, Tianyang Zhang²

¹State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, School of Resources and Environmental Engineering, East China University of Science and Technology, Shanghai 200237, China.

The Science of the total environment

|June 21, 2024

概括

新德里金属β-乳糖酶-1 (NDM-1) 细菌已经在全球62个国家传播,主要来自医院来源. 由于潜在的横向基因转移,这对公共卫生构成重大风险.

科学领域:

微生物学微生物学
公共卫生公共卫生
遗传学遗传学是一个

背景情况:

新德里金属β-乳糖酶-1 (NDM-1) 对大多数β-乳糖抗生素具有耐药性,这对全球健康构成了重大挑战.
携带NDM-1的细菌的全球分布,来源和转移风险仍然不完全理解.

研究的目的:

综合分析全球传播模式,细菌物种,来源以及与携带BlaNDM-1细菌相关的水平基因转移风险.

主要方法:

进行了系统的文献审查,分析了2010-2022年的数据.
收集和分析了有关细菌物种,地理分布,隔离源和与bla_NDM-1相关的遗传元素的数据.

主要成果:

在62个国家发现了超过6000种携带NDM-1的细菌,其中沿海地区的流行率较高.
克莱布西埃拉种类,埃舍里希亚种类,阿辛托巴克特种类和伪虫种类. 是占主导地位的物种.
医院,特别是患者和废水,是主要的来源 (86.45%),与表面水和农场的隔离程度有限.
在Acinetobacter sp.中的等离子体编码的bla_NDM-1. 呈现出多个抵抗机制.
与bla_NDM-1基因集群相邻的插入序列表明了转子子介导的水平基因转移的风险.

结论:

全球范围内的NDM-1携带细菌的广泛传播,主要来自医疗机构,需要采取强有力的控制措施.
已确定的横向基因转移机制突出显示了进一步传播的潜力,以及迫切需要监测和干预策略.

关键词:

抗生素耐药性基因是抗生素耐药性的基因.全球分销全球分销横向的基因转移是可以实现的.医院医院医院医院医院 bla (NDM-1) 的意思是"没有"的.

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