相关实验视频
Updated: May 9, 2026
10:33
Generation of Alginate Microspheres for Biomedical Applications
Published on: August 12, 2012
20.8K
生物降解酸盐基纳米载体的配方,用于体外药物输送和抗菌活性
Sobia Sattar1, Muhammad Imran1, Ayesha Anwar1
1Institute of Chemistry, Baghdad-ul-Jadeed Campus, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.
International journal of biological macromolecules
|June 21, 2024
概括
这项研究开发了基于酸盐的纳米载体,加载了西普罗夫洛克萨,用于控制药物释放. 这些纳米载体表现出显著的抗菌活性和稳定性,显示出有效的药物输送应用的潜力.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 制药科学 制药科学
背景情况:
- 控制药物释放系统对于提高治疗疗效和患者服药性至关重要.
- 基于酸盐 (ALG) 的纳米载体为药物输送提供生物相容性和可调性特性.
- 在纳米载体中集成的金属氧化物 (CeO2/ZnFe2O4) 可以增强稳定性并引入协同效应.
研究的目的:
- 为了合成和表征基于酸盐的纳米载体 (CeO2/ZnFe2O4/ALG),用于控制释放西普洛素 (CIP.HCl).
- 评估开发的纳米载体的体外释放动力学和抗菌疗效.
主要方法:
- 纳米载体是使用共同沉方法制备的.
- 描述涉及FT-IR,PXRD,SEM和泽塔潜力 (ZP) 分析.
- 进行了药物加载,不同pH值和温度的体外释放研究以及抗菌活性测定.
主要成果:
- 通过表征技术证实了CeO2/ZnFe2O4/ALG纳米复合物的成功合成.
- 高药物载荷能力 (~25%) 和加载CIP的纳米载体 (负ZP) 的增强稳定性.
- 在24小时内在各种pH值中观察到控制的体外释放西普罗夫洛克萨,具有显著的抗菌活性,可以对抗S. aureus和E. coli.
结论:
- 载有CeO2/ZnFe2O4的酸盐基纳米载体对控制的in vitro释放西普洛素是有效的.
- 开发的纳米载体表现出有希望的稳定性和抗菌性质,适合用于制药应用.
相关概念视频
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...