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麦康奈尔的标志预测了急性肺栓塞患者的正常压力休克
Robert S Zhang1, Aaron J Rhee2, Eugene Yuriditsky1
1Division of Cardiovascular Medicine, NYU Grossman School of Medicine, New York, NY, USA.
Journal of cardiology
|June 21, 2024
概括
麦康奈尔的标志可能有助于识别中等风险肺栓塞 (PE) 的患者,这些患者正在经历正常压力休克. 这种非侵入性标志在预测这种危急状况方面表现有前途,有助于及时诊断和治疗.
科学领域:
- 心脏病学 心脏病学
- 肺部医学 肺部医学
- 关键护理医学 关键护理医学
背景情况:
- 中级风险的肺栓塞 (PE) 患者与正常压力休克面临较差的结果.
- 诊断常压性休克通常需要侵入性血液动力学监测.
- 麦康奈尔的标志,一个特定的心声回声检测发现,可能提供一个非侵入性的替代冲击检测.
研究的目的:
- 评估麦康奈尔标志的预测能力,以识别中等风险PE患者的正常压力休克.
- 评估麦康奈尔标志与主要血液动力学和临床冲击标志物之间的关联.
主要方法:
- 对经过皮肤性机械血栓切除术的中等风险PE患者的回顾性分析 (2020年8月 - 2023年4月).
- 按特定标准定义的常态压力冲击:SBP ≥90 mmHg,没有血管压缩剂,CI ≤2.2 L/min/m2,临床低输液.
- 主要结局:麦康奈尔标志与正常压力休克存在之间的相关性.
主要成果:
- 麦康奈尔标志存在于72.5%的患者中,与心率升高,乳酸水平升高和心脏指数降低有关.
- 患有麦康奈尔征兆的患者表现出显著更高的正常压力休克率 (76%对27%,p=0.005).
- 麦康奈尔的标志显示88%的灵敏度和53%的特异性对于正常压力休克,赔率比为8.38 (p=0.008).
结论:
- 麦康奈尔的标志显示了作为中等风险PE中正常压力休克的非侵入性指标的潜力.
- 这一发现可能有助于更早地识别高风险患者.
- 建议对更大的患者队伍进行进一步的研究,以验证这些初步结果.
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