肺病学家的态度和在精准医学中的作用 测试非小细胞肺癌的生物标志物
Adam H Fox1, Mark A Rudzinski2, Paul J Nietert3
1Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, SC.
Chest
|June 21, 2024
概括
肺科医生经常将肺癌生物标志物测试推迟到瘤学,尽管它们在诊断中发挥着关键作用. 许多人认为缺乏知识或资源是订购这些必不可少的精确医学测试的障碍.
科学领域:
- 在瘤学瘤学.
- 肺部病理学 肺部病理学
- 精准医学是一门精准的医学.
背景情况:
- 生物标志物测试对于非小细胞肺癌 (NSCLC) 的精准医学至关重要,但面临着使用不足和不公平.
- 肺科医生在早期肺癌诊断中至关重要,但他们的实践和对生物标志物检测的知识各不相同.
- 了解肺病学家关于他们在肺癌治疗中的作用的观点是必不可少的.
研究的目的:
- 调查肺科医生如何看待他们在肺癌护理中的责任,特别是在生物标志物测试方面.
- 确定影响肺病学家参与订购NSCLC生物标志物测试的因素.
主要方法:
- 一项电子调查评估了肺病学家对NSCLC诊断步骤的态度和做法.
- 分析了美国胸部医生学院 (CHEST) 分析数据库中的401名肺病学家的数据.
- 使用了推理统计,包括千二测试和后勤回归.
主要成果:
- 62%的肺病学家报告说,他们订购了生物标志物测试,与此实践相关的实践时间更长,病例数量更高.
- 大多数受访者认为肺病学主要负责初始活检 (83%),但对生物标志物订购 (22%) 的责任较小.
- 不订购测试的主要原因包括:对瘤学的责任感 (84%),实践范围的局限性 (46%) 和知识差距 (51%).
结论:
- 肺病学家在订购生物标志物的过程中表现出不同的做法,经常将其推迟到瘤学.
- 许多肺科医生不领导生物标志物测试讨论或订购,尽管有指导方针和他们在支气管镜检查和分期中的作用.
- 缺乏资源和多学科支持,阻碍了肺病学家对生物标志物进行有效的检测.
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