小细胞肺癌的性别特异性从免疫疗法进步的小细胞肺癌
You Mo1, Yiwei Qin2, Jian Shangguan3
1Laboratory of Molecular Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong, China.
Archivos de bronconeumologia
|June 21, 2024
概括
对于非小细胞肺癌 (NSCLC) 和小细胞肺癌 (SCLC),肺癌死亡率从2016-2019年显著下降. 免疫疗法的使用可能解释了这些改善,特别是在SCLC的女性中.
科学领域:
- 在瘤学瘤学.
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 肺癌治疗的进步提高了生存率.
- 评估非小细胞肺癌 (NSCLC) 和小细胞肺癌 (SCLC) 对死亡率趋势的贡献,考虑到性别差异,至关重要.
研究的目的:
- 根据亚型和性别分析肺癌死亡率趋势.
- 评估最近的治疗进展对肺癌结局的影响.
主要方法:
- 基于亚型,性别和日历年 (2001-2019) 的肺癌死亡率数据的分析.
- 利用Joinpoint软件识别发病率和死亡率趋势的变化.
主要成果:
- 从2001年到2019年,NSCLC和SCLC的发病率和死亡率每年都在下降,而从2016年到2019年,这一下降幅度最大 (每年5.71%).
- 在女性中,基于SCLC发病率的死亡率下降了5.23% (2016-2019),而发病率下降了2.59%.
- 女性的生存率显著改善,SCLC免疫治疗患者的平均整体存活时间为23个月,男性为13个月.
结论:
- 在美国,从2016年到2019年,NSCLC和SCLC的人口死亡率急剧下降,这与发病率下降和生存率提高相吻合.
- 观察到的死亡率降低可能与免疫治疗的批准和使用有关,对患有SCLC的女性显示出显著的益处.
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