肠道微生物群与甲状腺疾病之间的关系
Marian E Ludgate1, Giulia Masetti2, Paula Soares3,4
1School of Medicine, Cardiff University, Cardiff, UK. Ludgate@Cardiff.ac.uk.
Nature reviews. Endocrinology
|June 21, 2024
概括
肠道微生物群在甲状腺疾病中起着至关重要的作用,包括自身免疫性甲状腺疾病 (AITD) 和甲状腺癌. 新出现的证据表明,肠道微生物群影响甲状腺健康,影响免疫调节和激素代谢.
科学领域:
- 内分泌学 在内分泌学.
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 甲状腺疾病很常见,特别是在女性中,包括自身免疫性疾病和癌症.
- 目前针对自身免疫性甲状腺疾病 (AITD) 的治疗方法侧重于治疗,而不是治疗,甲状腺癌是最常见的内分泌恶性瘤.
- 虽然已知遗传因素,但甲状腺疾病患病率的增加表明环境影响,如肠道微生物群,参与其中.
研究的目的:
- 探索肠道微生物群在甲状腺疾病 (包括AITD和甲状腺癌) 的发展和进展中的作用.
- 研究肠道微生物功能,如免疫调节和甲状腺激素代谢,如何影响甲状腺健康.
- 综合当前关于肠道微生物群对AITD和甲状腺癌的影响的证据,考虑人类和动物研究.
主要方法:
- 在动物模型中进行的观察和干预研究的综述,研究肠道微生物群对AITD的影响.
- 对人类队列研究的分析,检查肠道微生物群组成和AITD之间的关联.
- 评估有限的报告和证据,将肠道失调与甲状腺癌的发展和进展联系起来.
主要成果:
- 动物研究和一些人类数据支持肠道微生物群在AITD中的作用,尽管存在地理差异.
- 肠道微生物群影响免疫系统调节,甲状腺激素代谢和致癌物处理,所有这些都与甲状腺疾病有关.
- 证据,虽然不如AITD那么广泛,但表明肠道失调和甲状腺癌之间存在关联.
结论:
- 肠道微生物群是甲状腺健康的重要因素,影响着自身免疫性甲状腺疾病和甲状腺癌.
- 了解肠道微生物组的机制为新的治疗策略和预防甲状腺疾病提供了潜在的途径.
- 需要进一步的研究来阐明肠道微生物群在甲状腺病理中的作用的精确相互作用和地理变异.
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