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对六种全乳房照射技术的剂量测量分析,这些照射技术在仰卧和俯卧的姿势下进行

Dong Wook Kim¹, Chae-Seon Hong², Junyoung Son³

¹Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, 50-1, Yonsei-Ro, Seodaemun-Gu, Seoul, South Korea, 03722.

Scientific reports

|June 21, 2024

概括

在乳腺癌放射治疗中,尽量减少毒性至关重要. 粒子束疗法 (PBT) 显著降低了对有风险的器官的辐射剂量,无论患者的位置如何,提供了一种有希望的方法.

科学领域:

辐射瘤学辐射瘤学
医学物理医学物理
癌症治疗方法癌症治疗方法

背景情况:

在乳腺癌放射治疗中,尽量减少与辐射相关的风险和毒性至关重要,以改善患者的治疗结果.
定制放射治疗技术和患者定位可以降低对正常器官的辐射剂量,并减轻与治疗相关的毒性.

研究的目的:

进行6种外部光束全乳房照射技术的剂量比较.
评估患者定位 (仰卧或俯卧) 对风险器官辐射剂量 (OAR) 和目标覆盖率的影响.
估计二次癌症风险并分析不同治疗场景中的OAR-OAR距离.

主要方法:

对14名乳腺癌患者的6种外部光束全乳房照射技术在仰卧和俯卧位置的剂量比较.
评估目标覆盖率和OAR剂量 (心脏,双侧肺,对侧肺).
计算二次癌症的绝对风险过剩,并分析目标体积和OAR之间的距离.

主要成果:

发现倾斜的定位在X射线放射治疗中降低了肺部暴露.
粒子束疗法 (PBT) 显著降低了对心脏和肺部的辐射剂量,无论患者的位置如何.
在弧度输送和静态输送PBT之间观察到目标符合性和OAR节省的微不足道差异.

结论:

与传统的外部光束技术相比,PBT在减少乳腺癌患者的OAR剂量方面具有显著的优势.
患者的位置在减少X射线放射治疗的肺剂量方面发挥着作用,但无论位置如何,PBT都能提供大量的节约.
这项研究提供了关键的剂量测量数据,以指导选择最佳的放射治疗技术和乳腺癌治疗的患者位置.

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