确定性和随机性细胞-细胞变异的协同和对抗效应
Søren Vedel1,2, Andrej Košmrlj3,4, Harry Nunns2,5
1Niels Bohr International Academy, Niels Bohr Institute, University of Copenhagen, Blegdamsvej 17, DK-2100 Copenhagen, Denmark.
Physical review. E
|June 22, 2024
概括
细胞多样性有助于种群在压力下生存并更快地生长. 这项研究模拟了随机和决定性变化如何对人口弹性有所贡献,揭示了在日益增加的压力下从随机到决定性主导的交叉.
科学领域:
- 细胞和人口生物学 细胞和人口生物学
- 数学建模的数学建模
- 生物物理学的生物物理.
背景情况:
- 细胞群体通过个体多样化,特别是增长率来实现集体弹性.
- 随机 (随机的生物化学噪声) 和决定性 (不对称的成分分布) 机制驱动细胞间的细胞变异.
- 这些变异机制对人口层面的应激耐受性的综合影响尚不清楚.
研究的目的:
- 通过数学建模和评估确定性机制对细胞间变异的贡献.
- 分析随机变化和确定性变化对压力下人口动态的协同效应.
- 预测这些变化如何影响人口增长和应激适应.
主要方法:
- 通过将细胞人口增长映射到Ising模型,开发了一个数学模型.
- 集成的Ising模型将分析结果纳入欧勒-洛特卡框架,以分析组合变化效应.
- 使用计算模拟和实验数据验证的模型预测.
主要成果:
- 确定性细胞-细胞变异与环境压力呈现近线性增加.
- 来自细胞细胞变化的人口增长优势从主要在低压力下随机转变为在高压力下决定性.
- 确定性变化最大限度地减少了人群损害,而随机变化可以抵消这种保护作用.
结论:
- 在压力下细胞群的弹性是由随机和决定性变化的复杂相互作用调节的.
- 了解这些机制可以识别耐压性致病细胞,为新的抗生素策略提供信息.
- 在较高压力下转向确定性变异主导的转变凸显了它在极端环境适应中的关键作用.
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