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来自植物来源的生物活性的研究生物信息学工具:进化和未来的前景

Natalia Rodríguez Longarela¹, Maria Paredes Ramos², Jose Manuel López Vilariño²

¹METMED Group, Chemistry Department, University of A Coruña, A Coruña, Spain.

Critical reviews in food science and nutrition

|June 22, 2024

概括

来自植物的生物活性提供健康益处,如抗炎和抗氧化作用. 生物信息学工具,特别是分子对接,加速了它们的发现和机制研究,补充了传统方法.

科学领域:

生物化学和生物信息学
食品科学与营养食品科学与营养

背景情况:

植物衍生生物活性具有显著的促进健康的特性,包括抗炎,抗氧化,抗高血压和抗糖尿病能力.
这些被越来越多地认为是增强人类健康和福祉的有价值的天然替代品.

研究的目的:

审查生物信息学和生物活性发现计算工具的进化,局限性和最近的进展.
提供对计算技术,特别是分子对接的关键洞察力,以阐明植物生物活性的功能机制.

主要方法:

在生物信息学中使用in silico预测方法来加速生物活性的发现.
将古典实验方法与生物信息学工具相结合,以实现具有成本效益和高效的发现过程.
采用分子对接模拟来理解功能背后的相互作用机制.

主要成果:

生物信息学显著加快了生物活性的识别,降低了研究成本.
分子对接是解释植物生物活性的功能机制的关键计算技术.
计算工具与实验验证 (体外/体内) 的整合为研究生物活性提供了一个强大的方法.

结论:

生物信息学数据库,软件和应用程序与经典方法的结合代表了对植物生物活性的全面研究有前途的战略.
计算技术,特别是分子对接,对于了解植物生物活性如何发挥它们的有益作用至关重要.
虽然计算方法加速了发现和机械洞察力,但体外和体内研究仍然对验证发现至关重要.

关键词:

生物活性酸是一种生物活性酸.生物信息学是一种生物信息学.数据库就是数据库.在分析中,分析.分子对接的分子对接.植物蛋白质植物蛋白质

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