药理干预治疗梅尼尔病:系统性审查和网络元分析
1Department of Otorhinolaryngology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Ear, nose, & throat journal
|June 22, 2024
概括
内皮质类固醇对Ménière的治疗比 gentamicin更有效.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 梅尼尔病 (Ménière's disease,简称MD) 是一种慢性内耳疾病,其特征是头,耳和听力损失.
- 内疗法是MD的常见治疗方法,常常使用健美素和皮质类固醇.
研究的目的:
- 为了评估 intratympanic gentamicin 和皮质类固醇在治疗Ménière病中的有效性和治疗后效果.
- 为了比较 gentamicin,methylprednisolone,dexamethasone 和安慰剂在管理MD症状方面的疗效.
主要方法:
- 在PubMed和Embase上对1995年至2023年10月的随机对照试验进行了系统的文献搜索.
- 用Stata 17对13项涉及559名参与者的精选研究的数据进行了元分析.
- 评估结果包括纯色调平均值,控制和耳管理.
主要成果:
- 在 gentamicin 和 dexamethasone 之间没有发现纯色平均值的显著差异.
- 与安慰剂相比,所有经过测试的静脉内注射 (丁胺素,甲基prednisolone,德克萨米他) 都显示出更好的控制.
- 德克萨米他对耳最有效,其次是甲基普雷迪尼索隆和 gentamicin.
结论:
- 药理干预措施,包括入耳内膜注射,在治疗Ménière病方面比安慰剂更有效.
- 虽然 جنت米辛有效治疗头,但皮质类固醇组合治疗在MD患者中显示出对听力损失和头症状的优越控制.
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