分析系统性炎症反应指数与冠状动脉血管病变的严重程度之间的相关性
Ting He1, Yinhua Luo2, Jingjing Wan2
1Department of Central Hospital of Tujia and Miao Autonomous Prefecture, Hubei University of Medicine, Shiyan, Hubei Province, China.
Biomolecules & biomedicine
|June 22, 2024
概括
系统性炎症反应指数 (SIRI) 与冠状动脉狭窄的严重程度相关,冠状动脉疾病 (CHD) 患者. 较高的SIRI水平预测更严重的狭窄,使其成为一个有价值的早期查标记.
科学领域:
- 心脏病学 心脏病学
- 生物标志物 生物标志物
- 炎症 炎症是一种炎症.
背景情况:
- 冠状动脉心脏病 (CHD) 构成了全球健康的重大负担.
- 评估冠状动脉狭窄症的严重程度对于患者管理至关重要.
- 需要用于早期检测和风险分层的新生物标志物.
研究的目的:
- 研究心血管疾病患者的系统炎症反应指数 (SIRI) 和冠状动脉狭窄严重程度之间的相关性.
- 评估SIRI对冠状动脉狭窄症严重性的预测值.
- 将SIRI的预测能力与其他炎症标志物进行比较.
主要方法:
- 分析了2990名接受冠状动脉血管造影的患者队列.
- 根西尼分数被用来量化冠状动脉狭窄症的严重程度.
- 使用接收器操作特征 (ROC) 曲线和多变量逻辑回归来评估预测值.
主要成果:
- 较高的SIRI水平与冠状动脉疾病的可能性和严重程度的增加显著相关 (P < 0.001).
- 最高的SIRI四分位数显示冠状动脉疾病的风险增加了2.25倍 (P < 0.001).
- 与PLR,MLR和NLR (P<0.001) 相比,SIRI显示了对狭窄程度的优异预测能力.
结论:
- 在心血管疾病患者中,SIRI是冠状动脉狭窄严重程度的强大,独立的预测因子.
- SIRI作为一个有效的早期查标志物,用于评估冠状动脉狭窄.
- 根据SIRI的指示,炎症在冠状动脉疾病的病理生理学中起着重要作用.
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