基因基因频率净数据库
Faviel F Gonzalez-Galarza1, Antony McCabe2, Eduardo J Melo Dos Santos3
1Department of Molecular Immunobiology, Center for Biomedical Research, Faculty of Medicine, Autonomous University of Coahuila, Torreon, Coahuila, Mexico. faviel.gonzalez@uadec.edu.mx.
Methods in molecular biology (Clifton, N.J.)
|June 22, 2024
概括
同位基因频率净数据库 (AFND) 提供了广泛的人口数据,用于免疫相关基因,包括HLA. 最近的更新包括下一代测序数据,增强其对各种研究领域的实用性.
科学领域:
- 免疫学 免疫学 免疫学
- 人口遗传学 人口遗传学
- 生物信息学是一种生物信息学.
背景情况:
- 基因基因频率网络数据库 (AFND) 是全球人类人口中免疫相关基因频率的关键在线资源.
- 它包含来自129个国家的1400多万个人的数据,涵盖了许多多态区域,包括人类白细胞抗原 (HLA) 系统.
研究的目的:
- 为了提供一个更新的概述的基因基因频率净数据库 (AFND).
- 突出AFND资源中最近的发展和增强的搜索功能.
主要方法:
- 汇编和整合来自全球不同人群的等位基因频率数据.
- 包括来自广泛人口样本的基因型原始数据和下一代测序数据.
- 开发和完善基于网络的搜索机制,以有效地检索数据.
主要成果:
- 现在AFND包含了来自1784个人口样本的数据,包括超过1400万个人的数据.
- 最近的新增包括来自85,000个个体的基因型数据和来自300万个个体的广泛的下一代测序数据.
- 该数据库支持广泛的应用,包括组织相容性,免疫学,流行病学和疫苗开发.
结论:
- AFND继续成为各种科学学科的研究人员的重要,不断扩大的资源.
- 持续更新和增强的搜索功能提高了人群遗传学和免疫学研究的可访问性和实用性.
- 数据库的全面数据支持个性化医疗和公共卫生倡议的进步.
相关概念视频
01:49Hardy-Weinberg Principle
72.1K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
72.1K
01:25What is Population Genetics?
57.9K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
57.9K
01:09Mutation, Gene Flow, and Genetic Drift
58.3K
In a population that is not at Hardy-Weinberg equilibrium, the frequency of alleles changes over time. Therefore, any deviations from the five conditions of Hardy-Weinberg equilibrium can alter the genetic variation of a given population. Conditions that change the genetic variability of a population include mutations, natural selection, non-random mating, gene flow, and genetic drift (small population size).
58.3K
03:33Genetic Drift
39.7K
Natural selection—probably the most well-known evolutionary mechanism—increases the prevalence of traits that enhance survival and reproduction. However, evolution does not merely propagate favorable traits, nor does it always benefit populations.
39.7K
01:25Genetic Variation
273
Genetic variation is the diversity in DNA sequences found among individuals of the same species. This diversity is crucial for a species' survival because it helps organisms adapt to environmental changes. Genetic variation begins with fertilization, where an egg and sperm cell merge. Each of these cells carries 23 chromosomes, up to 46 in the fertilized egg. Chromosomes are long DNA strands that contain genes, the basic units of heredity.
Genes exist in different versions called alleles,...
Genes exist in different versions called alleles,...
273
01:21Frequency-dependent Selection
22.0K
When the fitness of a trait is influenced by how common it is (i.e., its frequency) relative to different traits within a population, this is referred to as frequency-dependent selection. Frequency-dependent selection may occur between species or within a single species. This type of selection can either be positive—with more common phenotypes having higher fitness—or negative, with rarer phenotypes conferring increased fitness.
22.0K