执行功能受损与患有的儿童血清维生素D水平较低有关
Shun Wang1, Haiju Zhang1, Liping Xia1
1Department of Pediatrics, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Epilepsy & behavior : E&B
|June 22, 2024
概括
患有的儿童经常有执行功能障碍和维生素D缺乏. 这项研究发现,较低的维生素D水平与这些儿童的执行功能不佳有关.
科学领域:
- 儿科神经学 儿科神经学
- 神经科学是一个神经科学.
- 内分泌学 在内分泌学.
背景情况:
- 执行功能 (EF) 障碍在患有的儿童中很普遍.
- 维生素D缺乏症在CWE中也很常见,并且可能会影响神经系统疾病中的认知功能.
研究的目的:
- 研究儿童执行功能状态与血清维生素D水平之间的关联.
主要方法:
- 在79名CWE患者和39名健康对照者 (HCs) 中使用执行功能-家长表格 (简要-P) 的行为评级清单来评估EF.
- 使用液体染色学-并联质谱法 (LC-MS/MS) 测量血清25-OH维生素D水平.
主要成果:
- 与HC相比,CWE患者的Brief-PT得分 (全球执行组合,行为调节指数,元认知指数) 和血清维生素D水平较低.
- 多变量回归表明,维生素D的1ng/ml增加与全球执行综合体,行为调节指数和元认知指数得分的下降有关.
结论:
- 降低维生素D水平与儿童执行功能障碍之间存在潜在的关联.
- 未来的研究应该探索与维生素D补充相关的EF的纵向变化.
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