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二氧化纳米颗粒通过微生物群-肠-大脑轴以尺寸特定的方式诱导类似焦虑的行为

Kaiyan Gong¹, Xiaoli Yin², Jiahui Lu²

¹Department of Endocrinology and Metabolism, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China.

Environmental toxicology and pharmacology

|June 22, 2024

概括

较小的二氧化纳米粒子 (SiO2-NPs) 在小鼠中显著增加了类似焦虑的行为. 这种效应与肠道微生物群的变化和炎症有关,这表明SiO2-NP的大小依赖的神经毒性作用.

科学领域:

纳米毒理学研究
神经科学是一个神经科学.
微生物组研究微生物组研究

背景情况:

二氧化纳米粒子 (SiO2-NPs) 越来越多地用于医药和食品.
了解SiO2-NP对大脑健康的大小影响至关重要.

研究的目的:

研究小 (NP-S) 与大 (NP-L) SiO2-NP对小鼠行为,肠道微生物群,炎症和氧化应激的影响.
探索SiO2-NPs暴露,肠道失调和类似焦虑的行为之间的关系.

主要方法:

小鼠被暴露在NP-S或NP-LSiO2-NP中12周.
进行了行为测试,肠道微生物群分析,以及对炎症和氧化应激标志物的评估.
相关性网络分析被用来确定行为,微生物群和分子变化之间的联系.

主要成果:

与NP-L相比,NP-S诱导了更明显的类似焦虑的行为.
暴露于SiO2-NPs会在结肠,海马体和皮质中引起尺寸特定的炎症和氧化应激.
类似焦虑的行为与特定的肠道微生物群变化相关 (例如,帕维巴克特,Faecalibaculum) 和改变的炎症标志物 (例如IL-10,Nqo1,Acox1,TNF-α).

结论:

SiO2-NPs暴露通过肠-大脑轴相互作用促进类似焦虑的行为.
较小的SiO2-NP可能对大脑健康构成更大的风险.
肠道微生物群调节和神经炎症是导致SiO2-NPs神经毒性的关键机制.

关键词:

焦虑焦虑是一种焦虑.肠-大脑轴肠-大脑轴炎症炎症是一种炎症.微生物群中的微生物群纳米颗粒纳米颗粒

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