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用迪苏尔菲拉姆加载的CuO2纳米载体,用于增强协同化学动力化学疗法

Wei Hu¹, Lianlian Yang¹, Hongtao Liao²

¹School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan 316022, PR China.

Journal of colloid and interface science

|June 22, 2024

概括

这项研究引入了一种使用二硫 (DSF) 和氧化铜 (CuO2) 纳米颗粒的新型双药输送系统. 这个系统有效地产生反应性氧物种 (ROS) 来杀死瘤细胞,显示出显著的抗瘤活性.

科学领域:

生物医学工程生物医学工程
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

当与铜离子 (Cu2+) 复合时,二硫 (DSF) 代谢产物显示出抗瘤潜力.
这种复杂化促进了活性氧物种 (ROS) 的产生,导致瘤细胞死亡.
开发有效的药物输送系统对于癌症治疗至关重要.

研究的目的:

开发一种新的双药物输送系统,用于增强癌症治疗.
利用氧化铜 (CuO2) 纳米颗粒作为DSF和Cu2+的载体.
研究开发系统的抗瘤疗效和瘤向能力.

主要方法:

在多多巴胺 (PDA) (DSF-CuO2@PDA) 中形成一个双药物输送系统,其中 CuO2 封装了 DSF 和 Cu2+ .
在瘤部位的CuO2的水解释放Cu2+和过氧化 (H2O2).
研究Cu2 +,DSF代谢物和H2O2之间的反应,以形成Bis ((diethyldithiocarbamate) -Cu (CuET) 并产生ROS.

主要成果:

通过DSF-CuO2@PDA系统,在瘤部位有效释放Cu2+和H2O2.
证实了CuET的形成和随后的ROS生成.
结合化学疗法和化学动力学疗法实现了61%的显著瘤抑制率.
该系统表现出卓越的瘤向能力和生物相容性.

结论:

开发的DSF-CuO2@PDA双药物递送系统通过ROS生成显示出强大的抗瘤疗效.
这种创新方法结合了化疗和化学动力学疗法,以改善癌症治疗.
该系统的优越瘤向性和生物相容性表明其具有临床应用的潜力.

关键词:

化疗和化学动力学疗法的化疗.这就是CuETET的意义.在CuO(2) 中.迪苏尔菲拉姆 (Disulfiram) 是一种芬顿式反应是一种类似芬顿反应的反应.

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