在苏拉威西山顶 (Macaca nigra) 中慢性肠球炎的组织病理学表征和分级
Yannick Van de Weyer1, Mark R Howard2, Mark F Stidworthy3
1Institute of Infection, Veterinary and Ecological Sciences, Department of Veterinary Anatomy, Physiology and Pathology, University of Liverpool, Leahurst Campus, Neston CH64 7TE, UK.
Journal of comparative pathology
|June 22, 2024
概括
苏拉威斯长期肠道疾病的马卡克表现出显著的结肠炎症. 纳西指数有效地诊断这些临灭绝的灵长类动物的炎症性肠病 (IBD),有助于标准化评估.
科学领域:
- 兽医病理学 兽医病理学
- 灵长类动物医学
- 保护生物学 保护生物学
背景情况:
- 苏拉威斯山顶 (Macaca nigra) 面临临危险的危险和在囚禁中患慢性肠道疾病的高率.
- 在这些灵长类动物中诊断慢性肠球炎是具有挑战性的,通常缺乏特定的病因学.
- 组织病理学评估对于了解SCM的胃肠道病理学至关重要.
研究的目的:
- 评估SCM中慢性肠道炎的临床症状和没有慢性肠道炎的肠道组织的组织学特征.
- 评估南希指数 (NI) 的实用性,这是一个人类IBD评分系统,用于评估SCM的结肠炎症.
- 为了比较患病和健康SCM的结肠中的炎症细胞种群.
主要方法:
- 从23个SCM (14个具有临床症状,9个对照) 的胃肠组织组织组织学检查.
- 使用南希指数 (NI) 对结肠组织的分类.
- 定量和对比炎症细胞类型 (淋巴细胞,血细胞,中性粒细胞,巨细胞) 在结肠膜本身.
主要成果:
- 中度至重度的淋巴细胞炎症和结构变化在受影响的SCM的结肠中普遍存在.
- 结肠NI与临床疾病严重程度有显著的相关性,57%的患病动物显示NI≥2 (中度至重度的IBD).
- 患病的SCM表现出显著增加的结肠淋巴细胞,血细胞,中性粒细胞,巨细胞和总白细胞数量.
结论:
- 纳西指数已被验证用于标准化对苏拉威西山顶的结肠炎症组织病理学评估.
- 这种评分系统有助于诊断SCM的炎症性肠病 (IBD) 状况.
- 在这种物种中,肠道炎症并不总是与直肠脱落有关.
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