减肥和对呼吸暂停-呼吸暂停指数的影响:一个系统的元分析
Atul Malhotra1, Cory R Heilmann2, Kushal K Banerjee3
1UC San Diego Health, La Jolla, CA, USA.
Sleep medicine
|June 22, 2024
概括
阻塞性睡眠呼吸暂停 (OSA) 患者的显著体重减轻改善了呼吸暂停-呼吸暂停指数 (AHI). 20%的BMI降低导致57%的AHI降低,而较大减肥的回报则减少.
科学领域:
- 睡眠医学 睡眠医学
- 代谢障碍 代谢障碍 代谢障碍
- 肥胖问题研究研究
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 是一种普遍的疾病,与肥胖密切相关.
- 现有研究表明,减肥可以改善OSA的严重程度,但确切的定量关系仍未得到充分研究.
研究的目的:
- 量化减肥与呼吸暂停指数 (AHI) 的变化与肥胖和OSA患者的体重减轻之间的关系.
主要方法:
- 对2000年至2023年间发表的研究进行了遵循PRISMA指南的系统文献搜索.
- 分析利用线性和二次模型来预测基于百分比体重减轻的AHI变化.
- 研究包括患有OSA (AHI ≥15/h) 和超重/肥胖的参与者,干预持续至少3个月.
主要成果:
- 分析包括27项研究 (32个治疗臂),主要涉及减肥手术和生活方式干预.
- 体重指数 (BMI) 降低20%与AHI降低57%有关.
- 进一步减轻体重超过20%的BMI,对AHI的影响逐渐减少,而广泛的预测间隔限制了精确的结论.
结论:
- AHI改善的程度与体重减轻的程度直接相关.
- 虽然显著的体重减轻是有益的,但大约20%的BMI减轻后,AHI的增量益处会减少.
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