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人类胆性淋巴激素调节了多发性硬化症患者的淋巴细胞的细胞因子生产

Lorena Juriol¹, Natalín Valeff¹, Marcos Dibo¹

¹Center for Pharmacological and Botanical Studies (CEFYBO-UBA-CONICET), Graduate School of Medicine, University of Buenos Aires, 2155 Paraguay St. 16th Floor, Ciudad Autónoma de Buenos Aires C1121ABG, Argentina.

Journal of reproductive immunology

|June 22, 2024

概括

人类胆性淋巴激素 (hCG) 可能为多发性硬化症 (MS) 提供新的治疗途径. 这项研究表明hCG通过减少促炎性细胞因子和增强抗炎性细胞因子来调节MS患者的免疫反应.

科学领域:

神经免疫学神经免疫学
生殖免疫学生殖免疫学
炎症性疾病炎症性疾病

背景情况:

多发性硬化症 (MS) 是一种慢性中枢神经系统炎症性疾病,影响年轻人,与与荷尔蒙变化相关的基于性别的免疫差异.
怀孕往往会改善多发性硬化症的症状,这归因于免疫适应,包括性激素和父性抗原.
人体胆性腺激素 (hCG) 是一种关键的怀孕激素,具有强大的免疫抑制特性.

研究的目的:

研究hCG对MS患者外围血液单核细胞 (PBMC) 中的细胞因子产生的免疫调节作用.
在MS的背景下,探索hCG调节促炎和抗炎细胞因子配置的能力.

主要方法:

从接受IFNβ1a治疗的17名多发性硬化患者的PBMCs与或没有hCG (复合或尿) 进行培养.
使用CBA阵列测量细胞因子的产量.
淋巴细胞细胞因子生产和B-淋巴细胞共刺激分子表达通过流动细胞计进行了分析.

主要成果:

hCG降低了MS PBMCs的瘤坏死因子 (TNF) 生产,包括产生TNF的T细胞和B细胞.
hCG显著增加了调节性T细胞和CD19高的B细胞的互白素-10 (IL-10) 生产.
在MS患者的B细胞上,hCG治疗降低了CD80+CD86+共刺激分子的表达.

结论:

hCG在多发性硬化症中表现出一种新的免疫调节作用.
hCG抑制促炎性细胞因子 (TNF) 和增强抗炎性细胞因子 (IL-10) 的能力表明MS的潜在治疗机制.
这些发现突显了hCG在治疗多发性硬化症方面尚未探索的途径.

关键词:

B 细胞 B 细胞 B 细胞细胞因子 (cytokines) 是一种细胞因子.多发性硬化症是多发性硬化症.怀孕怀孕怀孕怀孕在T细胞,T细胞.

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