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Updated: Jun 23, 2025

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关于EGFRvIII的作用和目标的结构性见解

Atrish Bagchi1, Steven E Stayrook2, Katerina T Xenaki3

  • 1Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.

Structure (London, England : 1993)
|June 22, 2024
PubMed
概括

对表皮生长因子受体变异III (EGFRvIII) 的结构洞察力揭示了其作为质母细胞瘤治疗点的潜力. 研究人员阐明了EGFRvIII细胞外区域结构,确定了针对性治疗的独特结合部位.

关键词:
VHH 域名 VHH 域名在X射线晶体学.皮肤上生长因子受体.皮肤上生长因子受体变体III.质母细胞瘤多形纳米体是一个纳米体.瘤原性突变是一种致癌性突变.

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