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炎症生物标志物调解多环芳暴露与失脂症之间的关联:一项基于全国人口的研究

Jiaqi Chen¹, Yurong Zhang², Ruijie Wu²

¹Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong, China; Department of Epidemiology, School of Public Health, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.

|June 22, 2024

概括

多环芳 (PAH) 暴露与成年人患脂质不良的风险增加有关. 血细胞炎症显著调解了这种关系,突出显示了监测环境污染物的必要性.

科学领域:

环境健康环境健康
流行病学流行病学
毒理学毒理学毒理学

背景情况:

失脂症是心血管疾病的重要危险因素.
多环芳 (PAH) 是常见的环境污染物,已知对健康有不良影响.
了解PAH暴露与脱脂症之间的联系对于公共卫生至关重要.

研究的目的:

调查暴露于多环芳 (PAH) 和失脂血症风险之间的关联.
在这种关系中识别出基于血细胞的炎症生物标志物的潜在调解作用.

主要方法:

采用国家健康和营养检查调查 (NHANES) 数据 (2001-2016) 来自8380名参与者的横截面研究.
利用了多重回归模型,包括通用线性回归,受限立方线,贝叶斯核机回归和加权定量数和回归.
评估个人和混合PAH暴露及其与脂质失调的关联,通过对炎症生物标志物的调解分析.

主要成果:

发现暴露于各种PAHs和增加脂质失调风险之间存在显著的积极关联.
贝叶斯核机回归表明PAH混合物和脂质失调之间存在正相关性,其中2-二 (2-FLU) 贡献最大.
调解分析显示,白细胞和中性粒细胞显著调解了PAH和脂质不良症之间的关联.

结论:

对PAHs的单个和混合暴露都与成年人患脂质障碍症的风险增加有关.
炎症生物标志物,特别是白细胞和中性粒细胞,在PAH-dyslipidemia路径中发挥着重要的调解作用.
需要对环境污染物及其健康机制进行进一步的监测和研究.

关键词:

共同暴露是指共同暴露.脱脂血症是什么意思脱脂血症是什么意思炎症生物标志物炎症生物标志物调解调解是一种调解.多环芳香碳化合物多环芳香碳化合物

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