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Updated: Jun 23, 2025

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
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14-3-3ζ通过破坏TRAF6的稳定性来抑制RANKL信号

R Ayyasamy1, S Fan2, P Czernik3

  • 1Department of Physiology & Pharmacology, College of Medicine & Life Sciences, University of Toledo, Toledo, Ohio, USA.

The Journal of biological chemistry
|June 22, 2024
PubMed
概括

14-3-3ζ蛋白通过调节TRAF6水平来抑制骨损失,抑制核因子-κβ连接体 (RANKL) 信号和骨质细胞活性的炎症受体激活剂. 这项研究揭示了骨重塑的新机制.

关键词:
在14-3-3ζζ中.兰克尔 (Rankl) 是一个名字.在TRAF6中,这就是为什么YWHAZ.骨质稳定性 骨质稳定性 骨质稳定性巨细胞是什么?巨细胞是什么?骨质结晶体的骨质细胞.蛋白质降解 蛋白质降解在任何地方都是无处不在的.

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