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通过模仿病毒的纳米粒子增强肺部传递和呼吸系统疾病的免疫调节

Yugo Araújo Martins¹, Isabel Cristina Guerra-Gomes², Tamara Silva Rodrigues³

¹Department of Pharmaceutical Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP 14040-900, Brazil.

Journal of controlled release : official journal of the Controlled Release Society

|June 22, 2024

概括

一个新的纳米素脂质颗粒 (NBL) 平台有效地将药物送到肺部,克服粘液屏障并减少炎症. 这一突破为治疗肺部疾病提供了新的策略.

科学领域:

纳米技术纳米技术
药物运输药物运输药物运输
肺部医学肺部医学

背景情况:

由于粘液屏障和炎症,肺部疾病在药物输送方面存在挑战.
现有的治疗方法在有效的粘液透和免疫调节方面扎.
呼吸系统病毒传输机制启发了新的传递策略.

研究的目的:

介绍和描述纳米素脂质颗粒 (NBL) 平台用于肺部药物输送.
评估NBL平台在肺模型中透粘液和调节炎症的能力.
评估NBL平台在治疗病毒引起的肺炎方面的潜力.

主要方法:

合成了由PEG涂层脂质纳米颗粒与赫辛化组成的NBLs.
分析了物理化学性质 (大小,泽塔潜力,pH,度).
评估了SARS-CoV-2感染肺细胞的粘粘度,粘液透,细胞毒性和免疫调节效应.

主要成果:

测量的NBL为118 ± 24nm,中性泽塔电位,pH为6.5,度为358mOsmol/kg.
NBLs表现出60%的粘素结合效率,成功透了粘液层,没有表皮细胞毒性.
治疗NBL显著增加了抗炎MUC1和IL-10的表达,同时减少了感染肺细胞中的促炎IL-6.

结论:

该NBL平台是有效的肺药物输送,克服粘液障碍的有前途的工具.
NBL 具有显著的粘粘性和粘液透性.
该NBL平台显示出强大的免疫调节作用,调节病毒感染肺细胞的炎症反应,这表明了肺部疾病的新型治疗方法.

关键词:

新冠病毒新冠病毒新冠病毒.炎症反应调节的调节.脂质纳米颗粒的使用方法减少粘液密度减少粘液密度病毒性呼吸道疾病病毒性呼吸道疾病

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