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益生菌对早产婴儿肠道微生物群的影响:一个系统性审查和元分析
Pandi He1, Leilei Yu1, Fengwei Tian1
1State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, Jiangsu, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, China.
Advances in nutrition (Bethesda, Md.)
|June 22, 2024
概括
益生菌显著改变了早产儿的肠道微生物群,丰富了像Bifidobacterium这样的有益细菌,减少了有害的细菌. 这项研究强调了益生菌.
科学领域:
- 微生物组研究的研究.
- 新生儿健康新生儿健康
- 益生菌的应用 益生菌的应用
背景情况:
- 早期的肠道微生物群对婴儿健康至关重要,尤其是早产婴儿.
- 益生菌对早产婴儿的肠道微生物群发育有影响,但具体的微生物变化尚不清楚.
- 现有的研究缺乏关于益生菌对早产婴儿肠道微生物组成的确切影响的共识.
研究的目的:
- 进行一项元分析,比较早产婴儿的肠道微生物群,是否暴露于益生菌.
- 在各种早产婴儿群体中识别微生物组成和预测功能的一致变化.
- 研究益生菌对早产婴儿肠道微生物群体类型和多样性的影响.
主要方法:
- 对5个微生物组数据集的元分析,包括来自706名早产婴儿的1816个便样本.
- 肠道微生物组成的比较和预测的功能途径之间的益生菌暴露和对照组.
- 与益生菌干预有关的微生物群体类型和α-多样性的分析.
主要成果:
- 在益生菌和对照组之间观察到肠道微生物组成和预测功能的一致差异.
- 丰富了Acinetobacter,Bifidobacterium和Lactobacillus spp.,并减少了Finegoldia,Veillonella和Klebsiella spp. 的含量. 在益生菌群体中.
- 益生菌促进了转向特定的早产肠道社区类型的转变,其中3型显示出Bifidobacterium和Bacteroides spp.的最高多样性和丰富性.
结论:
- 益生菌在分类学和功能层面上显著重塑了早产婴儿的肠道微生物生态系统.
- 在接受益生菌补充的婴儿中,糖糖生物合成的持续增加和血红蛋白生物合成途径的减少被预测.
- 需要进一步的标准化研究,以了解益生菌-微生物群-疾病风险相互作用,以改善婴儿营养指导.
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