低剂量胺注射对接受开放心脏手术的儿童片消费的影响:一项随机对照双盲研究
Mahmoud Abdelfattah1, Ibrahim Abdelbaser1, Karim Ali Awad1
1Department of Anesthesia and Surgical Intensive Care, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Journal of cardiothoracic and vascular anesthesia
|June 22, 2024
概括
低剂量胺注射显著减少了接受开放心脏手术的儿童的阿片类药物使用和疼痛. 这种麻醉方法被证明是安全的,没有增加诸如幻觉等不良反应的发生率.
科学领域:
- 麻醉学 麻醉学
- 儿科手术 儿科手术
- 药理学 药理学是指药理学的学科.
背景情况:
- 儿科开放心脏手术往往需要大量的外科手术期间的阿片类药物止痛.
- 在这个人群中,管理疼痛和与阿片类药物相关的副作用是一个临床挑战.
研究的目的:
- 评估低剂量胺注射在减少接受开放心脏手术的儿科患者外科手术期间阿片类药物消耗方面的疗效.
- 评估低剂量胺在这个患者群体中的安全性.
主要方法:
- 一项随机,双盲,受控的研究在一家三级医疗儿童医院进行.
- 最初招募了80名接受开放心脏手术的儿科患者 (2-12岁).
- 患者接受低剂量胺注射或盐水安慰剂,主要结论是阿片类药物消耗和疼痛评分.
主要成果:
- 与对照组相比,胺基组的手术内和24小时术后芬太尼消费量显著降低.
- 修改后的客观疼痛评分在胺组显著降低.
- 输出的时间和诸如双眼眼或幻觉等不良事件的发生率在两组之间是相似的.
结论:
- 低剂量胺注入有效降低阿片类药物需求和手术后疼痛,在接受开放心脏手术的儿科患者.
- 在研究的剂量中服用胺素并没有增加严重不良反应的发生率,如双眼视或幻觉.
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