对病原体耐药性的长期平衡选择在浮游生物甲类动物中保持了跨物种的多态性
Luca Cornetti1,2, Peter D Fields1, Louis Du Pasquier1
1Department of Environmental Sciences, Zoology, University of Basel, Basel, Switzerland.
Nature communications
|June 22, 2024
概括
在甲类动物中发现了跨物种多态性,物种分歧之前的遗传变异. 这些与免疫相关的基因表明长期宿主-寄生虫共同进化维持了遗传多样性.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 均衡选择通过防止等位基因固定来维持遗传多样性.
- 跨物种多态性 (TSPs) 发生在多态性发生在物种化之前,并在各个谱系中保持时.
- TSPs很少见,特别是在疾病基点,但与宿主-寄生虫共同进化 (红皇后动态) 有关.
研究的目的:
- 在具有深度进化分歧的甲类动物中识别跨物种多态性.
- 调查平衡选择在维持这些多态形态的作用.
- 探索TSP在宿主-寄生虫相互作用中的功能相关性.
主要方法:
- 三种甲类物种的全基因组扫描,分离超过1500万年.
- 识别相同的后裔跨物种多态.
- 对分子足迹的分析表明了平衡选择.
- 已识别的基因的功能注释.
主要成果:
- 确定了11个基因,在所有三种物种中共享相同的TSP.
- 其中四个基因显示出平衡选择的分子特征.
- 三个精选的基因与免疫有关,位于与对细菌病原体耐药性相关的位置附近.
- 在与宿主-寄生虫相互作用功能相关的基因中展示了TSP.
结论:
- 提供了通过宿主寄生虫共同进化的免疫相关基因中TSP的罕见证据.
- 支持对抗性共同进化可以在数百万年内保持遗传多样性的理论.
- 突出了平衡选择在保护疾病耐药性局部的适应变异中的作用.
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