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Updated: Jun 23, 2025

Antigenic Liposomes for Generation of Disease-specific Antibodies
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通过在脂质体上定的酸,T细胞独立抗体反应与类切换和记忆

Ásdís Hjálmsdóttir1, Fabio Hasler1, Ying Waeckerle-Men1

  • 1Department of Dermatology, University of Zurich, Zurich, Switzerland.

NPJ vaccines
|June 22, 2024
PubMed
概括

新的脂质体疫苗诱导T细胞独立抗体反应和B细胞记忆,即使在免疫受损的个体. 这一突破为当T细胞免疫力受到损害时提供了有效疫苗接种的潜力.

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
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T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
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The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
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