在I-131治疗后,与差异化甲状腺癌相关的眼器官功能障碍的最新情况
Chunlan Liang1, Changlin Wu1, Lian Liu2
1Department of Ophthalmology, The First Affiliated Hospital of Jinan University, 613 West Huangpu Ave, Guangzhou, 510632, China.
International ophthalmology
|June 22, 2024
概括
对差异化甲状腺癌的放射性 (I-131) 治疗可能会导致干眼和鼻管阻塞. 需要进一步的研究,以了解确切的机制,并开发有效的治疗这些常见的并发症.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
背景情况:
- 差异化甲状腺癌 (DTC) 治疗通常涉及放射性 (I-131) 治疗.
- I-131治疗可能导致显著的眼器官功能障碍,包括干眼和鼻管阻塞 (NLDO).
- 这些情况会对患者的生活质量产生负面影响,需要有效的管理策略.
研究的目的:
- 在DTC患者中全面审查和分析目前对I-131诱导的眼器官功能障碍背后的机制的理解.
- 总结和评估这些眼部并发症的现有和新兴治疗方案.
主要方法:
- 在CNKI,PubMed和Web of Science数据库中进行了系统的文献搜索,直到2023年12月.
- 关键词包括"甲状腺癌"",I-131"",并发症"",眼睛干燥"",眼"",眼"",鼻"和"NLDO".
主要成果:
- I-131治疗会损害眼腺和鼻管系统,导致眼睛干燥,眼和分泌物.
- 研究正在探索风险因素和治疗方法,但机制仍在争论中.
- 潜在的机制包括被动的I-131流,通过酸同载体 (NIS) 的积极吸收,或二次激素变化.
结论:
- 眼科医生的早期检测和预防措施对于管理I-131相关的眼功能障碍至关重要.
- 需要进一步的研究,以充分阐明这些并发症的潜在机制.
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