大动脉硬与非裔美国人的心脏结构和功能之间的亚临床关联:杰克逊心脏研究
Mawra Jha1, Solomon Musani2,3, Inbar McCarthy4
1Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, RW-453, Boston, MA, 02215, USA.
The international journal of cardiovascular imaging
|June 22, 2024
概括
大动脉硬与没有心血管疾病 (CVD) 的黑人成年人左心室 (LV) 功能不良的早期迹象有关. 这种关联似乎局限于LV的底部,表明亚临床心脏变化的特定模式.
科学领域:
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 造成了严重的健康负担,特别是在黑人成年人中,发病率和死亡率很高.
- 有限的数据存在于主动脉硬和左心室 (LV) 功能和重塑之间的亚临床关系,特别是在黑人群体内.
研究的目的:
- 为了调查大动脉硬和LV结构和功能之间的详细的亚临床关联在没有流行心血管疾病的黑人成年人中.
- 探索左心室内这些关联的区域差异.
主要方法:
- 利用心血管磁共振 (CMR) 成像在1050美国黑人成年人从杰克逊心脏研究没有心血管疾病.
- 使用脉冲波速度 (PWV) 测量 (大动脉门[AA-PWV]和胸前大动脉[T-PWV]) 评估区域和全球大动脉硬度.
- 评估了LV结构和功能,包括LV质量与身体表面积 (LVMI) 进行索引,终端透气体积 (LVEDV),射出分数 (EF),以及全球和区域周边应变 (Ecc).
主要成果:
- 更高的大动脉硬度 (AA-PWV和T-PWV) 与增加的LV质量与身体表面积 (LVMI) 相关.
- 大动脉硬度增加 (AA-PWV和T-PWV) 与左心室底部的更糟糕 (更积极) 周围应变 (Ecc) 相相关,但不在中部LV或顶部.
- 在大动脉硬度参数和LV质量/LVEDV或射出分数 (EF) 之间没有发现显著的关联.
结论:
- 在没有心血管疾病的黑人成年人中,大动脉硬与亚临床不良的LV功能有关,特别影响基底段.
- 这些发现突出了与大动脉硬相关的亚临床心脏变化的潜在局部模式.
- 需要进一步的研究,以了解大动脉硬与LV重塑,功能障碍和黑人患者相关预后的进展之间的时间关系.
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