在中国河南生产卡巴酶的グラム阴性细菌的分布和分子特征
Chenyu Li1, Ruyan Chen1, Jie Qiao2
1Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Scientific reports
|June 22, 2024
概括
在河南省,产生碳酶的グラム阴性细菌 (CPGNB) 感染正在增加. 克莱布西拉肺炎和大肠杆菌是常见的,其中KPC和NDM碳烯酶占主导地位,构成公共卫生挑战.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 传染性疾病 传染性疾病
背景情况:
- 碳酶产生格拉姆阴性细菌 (CPGNB) 构成了全球严重的健康威胁.
- 了解CPGNB的流行病学对于有效的感染控制至关重要.
研究的目的:
- 调查河南省CPGNB的流行病学特征和时间趋势.
- 为了确定CPGNB分离物中占主导地位的物种和carbapenemases.
主要方法:
- 从2019年4月到2023年2月,收集了5705个多药耐药格拉姆阴性细菌 (MDRGNB) 隔离物.
- 使用Vitek2和MALDI-TOF进行物种识别.
- 通过PCR检测碳烯耐药基因,并通过碳烯失活试验进行验证.
主要成果:
- 1918年CPGNB分离物被确定,主要来自呼吸道标本.
- 重症监护室 (ICU) 是CPGNB菌株的主要来源.
- 最常见的CPGNB物种是Klebsiella pneumoniae,Escherichia coli,Acinetobacter baumannii和Pseudomonas aeruginosa,其中KPC和NDM是主要的碳烯酶.
- 观察到抗卡巴胺感染的显著增加趋势.
结论:
- 河南省CPGNB感染的流行率和复杂性正在增加.
- 调查结果强调,迫切需要加强监测和控制策略,以减轻CPGNB的传播.
- 疫情后的时代,由于CPGNB的兴起,公众安全面临着更大的挑战.
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